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Using this route, released glutamate is almost quantitatively taken up by astrocytes (Danbolt, 2001), and either converted to glutamine and reintroduced in the glutamineglutamate (GABA) cycle, or metabolized to -ketoglutarate by glutamate-dehydrogenase (GDH) or aspartateglutamate transferase (AAT), followed by -ketoglutarate oxidation after malate exit and decarboxylation
Additionally, injections can be given twice a week if deemed appropriate
It works best when: Combined with sunscreen and skincare Paired with a nutrient-rich diet Taken consistently over time Think of it less like an overnight fix and more like a strategic ally for long-term skin wellness
Physiological Reviews
The timeline for feeling these anti-inflammatory effects varies from person to person, but many notice improvements within hours of treatment
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