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In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)
Can Patients Switch From Injectables to Pills
While this typically means morning administration for many patients, the critical factor is taking it before the first intake of the day, which may be at different times for shift workers
Dose: 15mg per day
They are especially beneficial for people with nutrient deficiencies or busy, active lifestyles
