The active ingredient, tirzepatide, has been approved for weight loss and is available in the United States under the brand name Zepbound
DPP-4 is an integral membrane protein which has a widespread distribution, being expressed in numerous tissues including intestinal and renal brush border membranes, vascular endothelium, the liver and pancreas, glandular epithelial cells, and by cells of the immune system (where it is also known as the T-cell differentiation antigen, CD26)
Darkening of Skin and Gums: A peculiar side effect seen in about 1% of female trial participants was hyperpigmentation darkening of the gums or skin (particularly on the face and breasts)
Sometimes good enough with perfect compliance beats optimal with inconsistent use
It can actually stimulate the creation of new muscle cells, a process called hyperplasia that most compounds simply cannot achieve