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Clinical and animal studies have demonstrated the efficacy of benfotiamine in the treatment of diabetes-related neuropathy, kidney disease, peripheral vascular disease, and retinopathy (Stirban 2006

Insulin therapy in patients with type 2 diabetes and high insulin resistance is associated with increased risk of complications and mortality

in late-stage type 2 diabetes, pancreatic beta cell dysfunction may necessitate exogenous insulin administration (Mayo Clinic 2014

By analyzing the single-cell RNA sequencing data of breast cancer PDXs (GSE123837), however, we found significant enrichment of several metabolic pathways and organic acid metabolic processes in lung metastases compared to primary tumors (Fig

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