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As shown in Figure 6A , GSH levels decreased to 2540% of control cells after AQ-QI or DEAQ-QI treatment, while the intracellular GSSG concentrations did not increase correspondingly, but decreased to approximately 4580% ( Figure 6B )
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By activating both receptor systems, tirzepatide appears to produce greater weight loss than GLP1 agonists alone
In contrast, GSH depletion drives M1 polarization, resulting in heightened secretion of pro-inflammatory cytokines, including TNF-, IL-6, and IL-1 (Kwon et al., 2019)
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