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However, these compounds have thus far not had been subjected to clinical trials, possibly because of unwanted side effects, including lower Ca 2+ transport or increased heme-oxygenase (HO-1) levels (Konorev et al., 2002)
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most cases appear to be sporadic, in which both genetic and environmental risk factors play a role 7 , while a small proportion arise from monogenic mutations
improved mitochondrial function
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