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Here's the math: At steady state on a 1 mg weekly dose, your blood concentration oscillates in a predictable pattern: Peak concentration: approximately 24 to 48 hours after injection Trough concentration: immediately before your next scheduled dose (day 7) The trough is roughly 50% of the peak due to one half-life of elimination When you inject one day early (day 6 instead of day 7), you're dosing when your blood level is at approximately 57% of peak instead of 50%

doi:10.1016/j.phrs.2025.108036

Pancreatitis is an uncommon but serious adverse effect associated with GLP-1 receptor agonists (occurring in approximately 0.10.2% of patients)

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