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Gilteritinib, a highly potent FLT3 inhibitor, has demonstrated promising clinical outcomes in adults with relapsed/refractory (R/R) FLT3-mutated AML [111]
Oxidative stress, marked by increased ROS production and GSH consumption, is implicated in various neurodegenerative and neuropsychiatric disorders such as Parkinsons disease, Alzheimers disease, multiple sclerosis, and schizophrenia 4,5
Therefore, the attraction between positively charged cationic nano-molecules and the negatively charged surface of the membrane, can work to facilitate the transport of these nano-molecules into the brain (70)
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