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Inhibiting GABA A receptors in the paraventricular nucleus of the hypothalamus (PVN), the control centre of the SNS, abolishes the enhancing effect on insulin secretion induced by OB GLP-1R

In both cellular and animal models, Epitalon shows promise in enhancing neuroplasticity, maintaining cholinergic tone, and reducing oxidative DNA damage, all hallmarks of both healthy brain aging and resistance to cognitive decline

The perspective outlined here emphasizes regenerative capacity relative to metabolic flux rather than absolute accumulation of reactive oxygen species

DOI: 10.1093/ajcn/86.5.1738 Montgomery SA, Thal LJ, Amrein R