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Endothelial dysfunction, which has been recognized as a key factor in the pathogenesis of diabetic microangiopathy and macroangiopathy, is characterized by a reduction in NO bioavailability
Tian T, Li X, Zhang J
The metabolic plasticity of cancer is not restricted only to cancer cells but extends throughout the TME (184, 185), as seen in CAFs that secrete lactate, lung mesenchymal-derived cells that transfer lipids, suppressing the functioning of NK cells, and arginine-depleting collagen-producing TAMs, leading to the suppression of CD8 + T cell functions
2012;17:S4958
