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Zepbound and diarrhea are well-documented in clinical trials, and the answer to "can Zepbound cause diarrhea" is unambiguous: it is one of the most commonly reported side effects of Zepbound (tirzepatide), a dual GIP and GLP-1 receptor agonist approved for chronic weight management and obstructive sleep apnea

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These co-exposures may result in additive, synergistic, or antagonistic effects, potentially modifying the respiratory toxicity of REEs