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prausnitzii populations by up to 34%

Ozempic works by imitating a natural hormone called glucagon-like peptide-1 (GLP-1)

Dose adjustment, slower titration schedules, or additional supportive measures can often alleviate symptoms whilst allowing continuation of therapy

In addition to acting through the p38 pathway, GLP-1RAs also promote the increase of PKA levels via the cAMP-dependent pathway, which in turn prevents the phosphorylation of epidermal growth factor receptor (EGFR) and activator of transcription 3 (STAT3), resulting in the inactivation of the EGFR-STAT3 signaling pathway in tumor cells and subsequently downregulating several downstream effector genes such as myelocytomatosis oncogene (c-Myc), survivin, cyclin D1, Bcl-xl, and Bcl-2, thereby inducing apoptosis in tumor cells in a dose-dependent manner [70, 73]

Receptor activation can be maintained for the duration of the experiment without dosing complexity