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Low SAM, excessive methylation demand, impaired creatine synthesis, reduced glutathione availability and oxidative stress may place additional strain on mitochondria, potentially contributing to fatigue, variable cognitive stamina, sensory sensitivity, poor stress tolerance and slow recovery from illness

Biotin also prevents hair loss and boosts hair follicle growth

These changes indicate the peptide is active even before hair changes become apparent

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Chapter 35: biological effects of estrogen on skin