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The brain is a GLP-1 organ GLP-1 and its receptor are expressed in the central nervous system, and several agonists cross the blood-brain barrier to varying degrees (West et al., 2025)

FGF21 selectively uses Klotho as its co-receptor, whereas, FGF23 uses Klotho

There have also been reports of these products containing contaminants or other medications altogether

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