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(2012) also found decreased hydroxyproline levels in patients with PKU (Mtze et al., 2012), which differ from findings in other studies (Jacob et al., 2018) that reported higher amounts of hydroxyproline

These observations highlight the need for large-scale, multicenter, randomized, placebo-controlled trials to ascertain whether targeted modulation of specific probiotic strains or other gut microbes associated with a lean phenotype can effectively counteract obesity and improve insulin sensitivity

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