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In one study, 12-week treatment with insulin glargine vs liraglutide (mean dose = 1.3 mg/day) showed similar glycemic control and decrease of hepatic fat burden, although a reduction in BMI was only observed in the liraglutide-treated patients (68)

This happened at much higher non-physiologically relevant concentrations than that stimulated by glucagon previously demonstrated by Samols group (Samols, Marri, Marks, 1966)

Cyclic Peptide Structure : Contributes to receptor-binding stability and defined signaling activity

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Ggebakan O, Kohl A, Osterhoff MA, van Baak MA, Jebb SA, Papadaki A, et al