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19% in the placebo arm had improvements in fibrosis, p = 0.004), though this did not translate into significant resolution of advanced fibrosis in those receiving OCA.84 Two adverse events occurred more commonly in those receiving OCA compared to placebo
263 Importantly, the same type of death may have opposite biological effects at different stages and even in different severity of AP
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A 2022 meta-analysis published in Nutrients reviewed 14 glutathione supplementation trials and found improvements in GSH/GSSG ratios and reductions in inflammatory markers (CRP, IL-6) but zero significant effect on weight, BMI, or waist-to-hip ratio
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