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By combining all three mechanisms, retatrutide aims to produce a synergistic effect on weight reduction and metabolic health

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In humans, acute administration of pharmacological doses of GLP-1 significantly induce satiety and reduce food intake (9193)

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While ertugliflozin did not outperform placebo for MACE, it significantly reduced hospitalizations for HF by 30% ( The SCORED clinical study, which included 10,584 patients with T2DM and an estimated glomerular filtration rate (eGFR) of 2560 ml/m/1.73 m, evaluated the effects of sotagliflozin on cardiovascular death and hospitalization for HF

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