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5-lipoxygenase knockout mice reduce the production of hepatic cytokine IL-1, TNF-, IFN-, and IL-10 in APAP challenge [233], and MIF knockout mice decrease IFN- production and increase HSPs expression [234], all these knockout mice attenuate AILI by decreasing IFN- production

The 2-hour post-meal window ensures a fasted state at the time of injection

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The authors concluded that while the combination showed limited effectiveness in the overall population, it might offer potential benefits for individuals with particular baseline features [76]

If weight loss targets are not met or side effects become problematic, alternative approaches should be considered