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Biology 11(2):212 Mikuov V, Miku P (2021) Advances in chitosan-based nanoparticles for drug delivery

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GHK, which declines with age, has health promoting effects on many tissues such as chondrocytes, liver cells and human fibroblasts, improves wound healing and tissue regeneration (skin, hair follicles, stomach and intestinal linings, boney tissue), increases collagen, decorin, angiogenesis, and nerve outgrowth, possesses anti-oxidant, anti-inflammatory, anti-pain and anti-anxiety effects, increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells

This lower affinity for IGF-binding proteins allows IGF-1 LR3 to remain in its active, unbound form, where it can bind to IGF-1 receptors