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Previous studies reported that dipeptidyl peptidase-4 (DPP-4) rapidly metabolizes GLP-1 into GLP-1 (9-36) amide, resulting in the loss of its insulinotropic activity [24,25]
It is reported that both DA-JC4 and DA5-CH could improve STZ-induced learning and memory impairment, reduce levels of phosphorylated tau protein and STZ-induced chronic inflammation response in brain (233, 237)
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