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Inositol plays a crucial role in cellular signaling and helps regulate both insulin and glucose metabolism [7]

B12 is crucial for red blood cell formation, neurological health, DNA synthesis, energy metabolism, and mood regulation

see Table 1) ( TABLE 1 Vitamin B12 Adequate Intake [AI] across life course ( Comparable age groupings are proposed in the Dietary Guidelines for Americans, though the recommended intake levels differ, beginning at 0.5 g in infancy, increasing to 2.4 g for adults, and rising modestly during pregnancy and lactation (2.6 g and 2.8 g, respectively

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further