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Together, they engage two separate hormonal systems that both regulate body weight creating an additive, and potentially synergistic, effect on appetite suppression and calorie reduction

Compounded GLP-1 drugs are a widely known and recent example of compounding

Symptoms are also often dose-dependent, meaning they may temporarily flare after a dose increase before settling back down

The insight that changed this view is that when glucagon receptor activation occurs alongside GLP-1 activity, the net effect is a shift toward increased energy expenditure and fat oxidation rather than hyperglycemia

GLP-1 receptor agonists also act in your brain to decrease hunger and slow down the speed at which your stomach empties