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They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding approximately 300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects
B12 and Older Adults While a B12 deficiency isnt as prevalent as something like vitamin D or folate, evidence suggests that 10-15% of people over the age of 60 are low in B12, likely due to loss of a protein called intrinsic factor, which is essential for the body to absorb vitamin B12
[8] Although not an absolute contraindication, patients with coronary artery disease or unstable angina should only use B-Complex injections containing niacinamide under physician supervision, since high-dose niacin supplements have been linked to arrhythmias in such patients
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