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Worryingly however, 26.8% of patients had to discontinue the trial due to the severity of side-effects, although it must be noted that this was in part due to the lack of a run-in (A time frame where drug dosage is started from a low dosage and then escalated over time until the highest tolerable dose for the patient is reached) [40]

The protocol was adapted from (Ruhela et al

Reduced glucose metabolism in AD may be a consequence of reduced postsynaptic neurotransmission, since depolarizing agents trigger glucose uptake in the brain and the effect is reduced in AD (1)