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Off-Label Prescribing Considerations Some healthcare providers are already discussing GLP-1 therapy with patients at high risk for both metabolic disease and dementia

doi: 10.1210/jc.2015-1841 23 RehmanSUsmanZRehmanSAlDraihemMRehmanNRehmanIet al

In CRISPR-engineered iPSC-derived microglia and neurons, plus primary autopsy microglia and brain tissue, SORL1 deletion triggered endoplasmic reticulum stress, interferon signaling, lipid-droplet accumulation, and impaired phagocytosis

The pervasive stereotype that plagues folks in larger bodies is that fast food and ultra-processed foods are to blame