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Additional support for this contention is supplied by consideration of the upregulation of glycogen synthase (1.39-fold, p=0.017), the increased presence of which implies an anabolic, ATP-replete cellular state

Patients on semaglutide 2.4 mg consume roughly 30-35% fewer calories 4, and those calories often come from less nutrient-dense choices because food aversions shift dietary patterns

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Patients should discuss their individual circumstances with their healthcare team, as recommendations may vary based on diabetes control, complications, other medications, and personal health history

doi: 10.1042/bj20021619 226