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As a member of the MAPK family, p38MAPK, ERK, JNK are activated by MAPKK to influence pro-inflammatory cytokines, such as TNF, IL-6, and IL-1 (131)
Volume depletion that may affect patients on diuretics or with chronic kidney disease
The characteristics are aggressive nature, involvement of lymph nodes, early recurrence, and a poor prognosis unless anti-HER2 therapy, like trastuzumab, pertuzumab, and ado-trastuzumab emtansine, is provided
PMID: 146 WangHRongXZhaoGZhouYXiaoYMaDet al
Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children
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