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However, benchmarking against SUSTAIN-6 flagged disagreement for the effect on all-cause mortality, highlighting potential residual confounding for this secondary endpoint that could reflect preferential prescribing in patients for whom clinicians anticipated limited life expectancy

These are a last resort for hemorrhoids that dont respond to other treatments or are particularly large

For example, if you have a faster metabolism, you may process the medication more rapidly and require a higher dose

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Prioritise bioavailability through liposomal or other advanced delivery technologies