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Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011
doi: 10.1002/hipo.23520, 52 GiacomelloM.PyakurelA.GlytsouC.ScorranoL
Nanoscale materials possess distinct risk profiles owing to their small size, enhanced biological reactivity, and unique physicochemical properties
