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Intravenous catheters were placed in the forearms of the participants for blood collection at d 0.30, 0.50, 1.0, 2.0, 4.0, 6.0, 8.0, 12.0 hours, and 24.0 hours post-drug cocktail administration

Under this hypoxic and high-fat dietary environment, adipose tissue exhibits significant immune cell infiltration (macrophages, T cells) accompanied by characteristic phenotypic shifts ( Local hypoxia during adipocyte hypertrophy also induces endoplasmic reticulum stress (ERS) (32, 33)

Furthermore, the protective association is significantly modified by age and smoking status