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Notably, mutant mice with diminished expression of renal sodium/lactate cotransporter proteins (SLC5A8 and SLC5A12) were found to display impaired uric acid reabsorption, resulting in an approximately eightfold elevation in UA levels [84]

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Given its high arginine content and polycationic nature, formulators typically account for hygroscopicity, potential trifluoroacetate counter-ion content from purification, and solubility behavior in aqueous versus mildly acidic reconstitution media when designing analytical experiments

4.3 Glutamine Glutamine (Gln) is mainly converted through GLS/glutamate dehydrogenase (GLUD)-related reactions to generate -KG, which enters the TCA cycle and provides anaplerotic substrates for oxidative metabolism, while also influencing polarization-related epigenetic regulatory processes through metabolic ratios such as -KG/succinate (58)