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ScGrx7 is poorly susceptible to competitive inhibitors To test the catalytic mechanism in more detail, we performed inhibition studies with S -methylglutathione or L--glutamyl-L--aminobutyrylglycine (ophthalmic acid)

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Conversely, the antifungal drug ketoconazole has been shown to inhibit P450 activity, leading to a decrease in SAMe production and impaired methylation