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if neurological involvement is present, maintenance is every two months Oral therapy is generally not appropriate where absorption is impaired (e.g., pernicious anaemia), as adequate levels cannot be reliably achieved Because B12 is water-soluble and any excess beyond hepatic storage capacity is excreted in the urine, it has a low toxicity profile
Most people get enough B12 from the foods they eat "without thinking about it," Gans says
After being extracted by gastric acid, it travels to the terminal ileum, where it is co-absorbed along with the intrinsic factor, an enzyme from the stomachs parietal cells (Fig
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