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Lorenzen JM, Thum T
The MHRA advises that metformin commonly reduces B12 levels and recommends testing if deficiency is suspected (for example, in patients with anaemia or neuropathy) and considering periodic monitoring in people with risk factors such as higher doses, longer duration of treatment, or other risk factors for deficiency
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[14] By injecting hydroxocobalamin, vitamin B levels can be restored, helping to resolve anemia, fatigue, neurological symptoms, and other complications of B deficiency
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