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The mechanism leading to 5-oxoprolinuria is the following: decreased activity of 5-oxoprolinase leads to decreased conversion of 5-oxoproline to glutamate
These include: Delaware Kansas Massachusetts Michigan Minnesota Mississippi Missouri North Carolina Rhode Island Tennessee Utah Virginia Wisconsin Four states have entirely eliminated coverage for GLP-1s for weight loss as of January 2026
Neurology 60, 100107
7 This presents the idea that GLP-1 RAs exert effects beyond weight loss or glycemic control, perhaps acting locally on immune cells or keratinocytes
Glick M
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