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However, they need to make sure the supplement provides acceptable amounts of vitamin B12 made from high-quality ingredients

Clin Ther 25: 31243134 Buttler CC, Vidal-Alaball J, Cannings-John R et al

A Vitamin B12 shot is a medical-grade intramuscular injection of cholecalciferol-quality, pure cobalamin (the active form of B12)

A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults

This is why some practitioners prefer it not just for multi-dose use but specifically because it's designed to remain chemically stable in a vial over an extended period