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No - it remains a research peptide
doi:10.1016/j.ocl.2016.03.005
Future investigations employing sequential single-cell transcriptomics, specific inducible gene knockouts, and clinical cohort stratification are urgently needed to elucidate these temporal dependencies, which will pave the way for precise, stage-targeted RCD-modulating therapies in DKD
Thiamine deficiency adversely affects the activity levels of these enzymes, with TK, through thiamine-dependent erythrocyte transketolase (ETK) activity, common biomarkers of thiamine status, since it is particularly sensitive to thiamine levels and AKD often exhibiting the earliest detectable changes (41)
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