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Zileuton, a 5-LOX inhibitor approved by the FDA and formerly employed in the treatment of asthma, is presently under evaluation for clinical trials in the management of PF [189]
Our skin faces oxidative stressan imbalance between free radicals and our bodys defensesfrom daily exposure to: UV Radiation: Sun exposure (remember to wear SPF 24/7) Environmental Pollutants: Smog, ozone, and particulate matter Lifestyle factors such as poor diet, stress, and lack of sleep
Skin improvements tend to become visible earliest, while hair growth requires the most patience
It also suppresses the oxidation of low-density lipoprotein, quenches hydroxyl and other reactive oxygen species, and chelates iron in a manner that blocks iron-driven lipid peroxidation
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