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Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease
Plasmid for single-stranded adeno-associated viral vectors 2/8 The plasmid pAAV-MCS-hAAT/EGFP was designed for maximum transgene expression and includes the hepatic locus control region from the ApoE gene (ApoE-HCR), a liver-specific 1-antitrypsin promoter (hAAT promoter), coagulation factor IX intron A (FIX intron A), a 3' mRNA transcription termination/polyadenylation signal (bghpA), and a reporter gene encoding enhanced green fluorescent protein (EGFP), as previously described (Miao et al
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Consequently, succinate dehydrogenase (SDH) reverses its catalytic direction, reducing fumarate to succinate using electrons from reduced ubiquinone, leading to substantial succinate accumulation (up to 10-fold increases) within minutes
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