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TGF-1 is an important cytokine that induces fibrosis in organs such as the kidneys and lungs [39, 40], and can activate PSCs to induce pancreatic fibrosis [41, 42]
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The most common ones are nausea, vomiting, diarrhoea, and constipation
In the acute stage, the most commonly noted histopathological feature is the peribulbar lymphocytic infiltrate, often described as a swarm of bees. However, this infiltrate may not be observed in some patients, especially in the advanced stages of the disease
In in vitro experiments, NRF2 expression was reduced in IL-22-stimulated HaCaT cells, while the addition of SFN partially restored NRF2 expression
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