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10.7717/peerj.11128 92 SinghA.FernandesJ.ChhabraG.KrishnaA.BanerjeeA

The S4 category covering hormone and metabolic modulators is also relevant to GLP-1, GIP, and glucagon receptor agonists generally

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The cagrilintide semaglutide mix achieves this through combined mechanisms: both peptides suppress appetite but through different brain pathways (hypothalamic GLP-1 receptors vs brainstem amylin receptors), both slow gastric emptying but through different receptor systems creating additive effects, both improve glucose control through paired mechanisms, and together provide more full body effects

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