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Long-term extension studies, such as ATTAIN, confirmed sustained reductions in relapses and lesion accumulation for up to six years, with many patients achieving no evidence of disease activity (199)

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Prolonged elevation of blood glucose, as well as related adverse metabolic features such as dyslipidemia and chronic inflammation, lead ultimately to a range of debilitating health issues such as, cardiovascular disease, peripheral neuropathy, diabetic ketoacidosis, diabetic retinopathy, and diabetic nephropathy