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A new initiative on precision medicine

The IVR domain contains a 3-box motif in its proximal part, which provides an additional CUL3 interaction site [116], and two critical cysteine residues, Cysteine273 (C273) and Cysteine288 (C288), that are important for the repression of NRF2 activity [126]

Patients with genetic slow-metabolizer phenotypes, liver disease, or chronic illness may warrant baseline and periodic testing

Lyophilised vials are stable for roughly 24 months at minus 20 degrees Celsius, 12 months at 2 to 8 degrees, and 6 months at room temperature if sealed

PintoCJGvila-GlvezMLianYMoura-AlvesPNunes Dos SantosC