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Originally developed as a prescription therapy for fat redistribution in HIV patients, this powerful growth hormonereleasing hormone (GHRH) analog is now used off-label by athletes and wellness enthusiasts to boost IGF-1, reduce visceral fat, and support lean muscle retention

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Metformin primarily reduces hepatic glucose production and improves peripheral insulin sensitivity, while tirzepatide enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety

PMID: 37463995 EMBO RepTargeting the transcription factor YY1 is synthetic lethal with loss of the histone demethylase KDM5C

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