Funding This work was supported by the National Key Research & Development Program of China (2023YFC2307302, 2023YFC2307000), the Noncommunicable Chronic Diseases-National Science and Technology Major Project (2024ZD0529003), the National Natural Science Foundation of China (82271797, 82341065, 82371825 and 32400727), the program of Shanghai outstanding academic leader in public health subject (GWVI-11.2-XD29), the experimental animal program sponsored by the Science and Technology Commission of Shanghai Municipality (23141902300), the Natural Science Foundation of Shanghai (24ZR1481100), the Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission (24CGA43), the Postadoctoral Fellowship Program for Innovative Talents and China Postdoctoral Science Foundation, and the Open Research Fund of Basic Medicine College of Naval Medical University (JCKFKT-ZD-002)

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The proximity to the lumbar spine may enhance local tissue concentrations while maintaining ease of self-injection
Both in vitro and in vivo results underscore its ability to attenuate inflammation, enhance antioxidant defenses, and promote extracellular matrix remodeling