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Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer's disease models

However, researchers saw that patients were experiencing a reduction in hunger and losing weight, enabling them to be licensed to treat obesity

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This targeted approach is what made it such a promising candidate for an anti-obesity drug and what continues to make it a fascinating subject for metabolic research today

Moreover, estrogen was reported to regulate proteolysis through the induction of protease inhibitors, preventing excessive degradation of extracellular matrix components that are essential for tissue repair (Horng et al., 2017)