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Hayyan M, Hashim MA, Alnashef IM
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At = 220 mOsm, ER vesiculation rarely occurred, at = 303 mOsm it did not reverse (Fig
While the drug initially showed promise in a Phase 2 study, a large Phase 3 trial failed to meet its primary endpoint, raising major doubts about efficacy.24 No trials of TUDCA alone have shown clear clinical benefit in ALS, and regulatory approvals for the combo have already been withdrawn in the U.S
Overall, data showed that systemic infection by ACLSV did not produce any visible symptoms or membrane damage in leaves (i.e., no changes in lipid peroxidation), while antioxidant defenses increased, including GST
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