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However, when the researchers adjusted for other things , including siblings with autism, the increased risk was no longer statistically significant .[ref][ref] (Note that other researchers point out bias in that paper.[ref]) Another large study published in 2021 involving 73,000 children and mothers found that there was a 19% increase in relative risk of ASD with prenatal acetaminophen exposure.[ref] A 2025 meta-analysis of studies on acetaminophen use during pregnancy and infancy shows that the majority of studies and the higher-quality studies show a positive association between acetaminophen use and ADHD, ASD, or neurodevelopmental disorders.[ref] A couple of things to consider here
Springer, New York, pp 2132 Lucas GNC, Leito ACC, Alencar RL, Xavier RMF, Daher EDF, Silva Junior GBD (2019) Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs
The appeal is not that it does one giant thing
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Its recommended to split up the dose into smaller portions to ensure maximum optimisation
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