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Uh, then what is the actual evidence for this concern

PIONEER 6 achieved its primary objective, confirming noninferiority for oral semaglutide versus placebo for cardiovascular safety in a high-risk population, with a non-significant 21 percent reduction in three-point MACE over a median follow-up period of just under 16 months, said lead investigator Mansoor Husain, MD, Director of the Toronto General Hospital Research Institute, Executive Director of the Ted Rogers Centre for Heart Research, and Professor of Medicine at the University of Toronto

It points to metabolic stability, which it places at roughly eight to twelve weeks into treatment, as the point where screening labs typically normalize and centers are more likely to approve donation

Fatigue is listed as a common adverse reaction in clinical trials for Wegovy, occurring in 5% of patients